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Peer-Reviewed Publications

Ray, L.A. (in press). Stress-induced and cue-induced craving for alcohol in heavy drinkers: genetic moderation by the OPRM1 and CRH-BP Genes. Alcoholism Clinical and Experimental Research.

Ray, L.A. Primack, J., Young, D., Chelminski, I., & Zimmerman, M. (in press). Treatment seeking men with and without substance use disorders. Psychology of Men and Masculinity.

Leventhal, A., Brightman, M., Ameringer, K.J., Greenberg, J., Mickens, L., Ray, L.A., & Sussman, S. (in press). Anhedonia associates with stimulant use and dependence in a population-based sample of American adults. Experimental and Clinical Psychopharmacology

Monti, P.M. & Ray, L.A. (in press). The study of craving and its role in addiction. In K. Brownelll & M. Gold (Eds.). Food and Addiction. New York, NY: Oxford University Press.

Ray, L.A. & Hutchison, K.E. (in press). Molecular genetics and the treatment of addiction. In B. Johnson (Ed.). Addiction Medicine: Science and Practice. Springer.

Ray, L.A., Krull, J.L., Leggio, L. (2010). The effects of naltrexone among alcohol non-abstainers: Results from the COBINE Study. Frontiers in Psychiatry, 10:3389.

Ray, L.A., Hutchison, K.E., Ashenhurst, J., & Morrow, A.L. (2010). Naltrexone selectively elevates GABAergic neurosteroid levels in heavy drinkers with the Asp40 allele of the OPRM1 gene: a pilot investigation. Alcoholism Clinical and Experimental Research, 34(8), 1479-1487.

MacKillop, J., O’Hagen, S., Lisman, S.A., Murphy, J.G., Ray, L.A., McGeary, J.E., Tidey, J.W., & Monti, P.E. (2010). Behavioral economic analysis of cue-elicited craving for alcohol. Addiction, 105(9), 1599-607.

Ray, L.A., Heydari, A., & Zorick, T. (2010). Quetiapine for the treatment of alcoholism: scientific rationale and review of the literature. Drug and Alcohol Review, 29(5), 568-575.

Ray, L.A., Hutchison, K.E., & Tartter, M. (2010). Application of human laboratory models to pharmacotherapy development for alcohol dependence. Curr Pharm Des, 16(19), 2149-2158.

Ray, L.A., MacKillop, J., & Monti, P. (2010). Subjective responses to alcohol as endophenotypes: advancing genetics into etiological and treatment models of alcoholism. Subst Use Misuse, 45(11), 1742-1765.

Ray, L.A., Chin, P.F., & Miotto, K. (2010). Naltrexone for the treatment of alcoholism: clinical findings, mechanisms of action, and pharmacogenetics. CNS & Neurological Disorders – Drug Targets, 9 (1), 13-22. [PDF]

Ray, L.A., Miranda Jr., R., Tidey, J.W., McGeary, J.E., MacKillop, J., Gwaltney, C.J., Rohsenow, D.J., Swift, R.M., & Monti, P.M. (2010). Polymorphisms of the mu-opioid receptor and dopamine D4 receptor genes and subjective responses to alcohol in the natural environment. Journal of Abnormal Psychology.

MacKillop, J., McGeary, J.E., Ray, L.A. (2010). Genetic influences on addiction: Alcoholism as an exemplar. In D. Ross, P. Collins, & D. Spurrett (Eds.). What is Addiction? (pp. 53-98).Cambridge, MA: MIT Press.

Ray, L.A.& Hutchison, K.E. (2009). Genetics of addiction. In L.M. Cohen, F.L. Collins, A. Young, D.E. McCheargue, T.R. Leffingwell, & K.L. Cook (Eds.). The Pharmacology and Treatment of Substance Abuse: Evidence and Outcomes Based Perspectives (pp. 109-126). Routledge.

Ray, L.A., Capone, C., Sheets, E., Young, D., Chelminski, I., & Zimmerman, M. (2009). Posttraumatic stress disorder with and without alcohol use disorders: diagnostic and clinical correlates in a psychiatric sample. Psychiatry Research.

Ray, L.A., & Oslin, D.W. (2009). Naltrexone for the treatment of alcohol dependence among African Americans: Results from the COMBINE Study. Drug and Alcohol Dependence.

Ray, L.A., MacKillop, J., Leventhal, A., & Hutchison, K.E. (2009) Catching the alcohol buzz: an examination of the latent factor structure of subjective intoxication. Alcoholism Clinical and Experimental Research.

Ray, L.A., MacKillop, J., & Monti, P. (2009). Subjective responses to alcohol as endophenotypes: advancing genetics into etiological and treatment models of alcoholism. Substance Use and Misuse.

Miranda, R., Ray, L.A., Justus, A., Meyerson, L.A., Knopik, V.S., McGeary, J., & Monti, P.M. (2009). Influence of the OPRM1 gene on adolescent alcohol misuse: mechanisms and moderators. Alcoholism Clinical and Experimental Research.

MacKillop, J., Miranda, R., Jr., Monti, P. M., Ray, L. A., Murphy, J.G., Rohsenow, D. J., McGeary, J. E., Swift, R. M., Tidey, J. W., & Gwaltney, C. J. (2009). Alcohol demand, delayed reward discounting, and craving in relation to drinking and alcohol use disorders. Journal of Abnormal Psychology.

Chen, Y-C, Holmes, A., McDevitt-Murphy, M.E., Murphy, J.G., Ray, L.A., Richardson, HN, Witkiewitz, K., & Cruz, M.T. (2009). Young investigator award symposium. Alcohol.

Ray, L.A., Hutchison, K.E., Leventhal, A., Miranda, R. Jr., Francione, C., Young, D., Chelminski, I., & Zimmerman, M. (2009). Diagnosing alcohol abuse in alcohol dependent individuals: diagnostic and clinical implications. Addictive Behaviors, 34, 587-92. [PDF]

Ray, L.A., & Hutchison, K.E. (2009). Associations among GABRG1, level of response to alcohol, and drinking behaviors. Alcoholism Clinical and Experimental Research. [PDF]

Ray, L.A., Miranda, R., Jr., MacKillop, J., McGeary, J. E., Tidey, J. W., Rohsenow, D. J., Gwaltney, C. J., Swift, R. M., & Monti, P. M. (2009). A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers. Experimental and Clinical Psychopharmacology. [PDF]

Ray, L.A., Bryan, A., MacKillop, J., McGeary, J., Hesterberg, K. & Hutchison, K.E. (2009). The Dopamine D4 receptor (DRD4) gene exon III polymorphism, problematic alcohol use, and novelty seeking: direct and mediated genetic effects. Addiction Biology.[PDF]

Ray, L.A., MacKillop, J., Leggio, L., Morgan, M., & Hutchison, K.E. (2009). Effects of naltrexone on cortisol levels in heavy drinkers. Pharmacology, Biochemistry, and Behavior. [PDF]

Magill, M., & Ray, L.A. (2009). Cognitive-behavioral treatment with adult alcohol and illicit drug users: a meta-analysis. Journal of Studies on Alcohol and Drugs, 70, 516-27.

Leggio, L., Ray, L.A., Kenna, G., and Swift, R.M. (2009). Blood glucose level, alcohol heavy drinking, and alcohol craving during treatment for alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study. Alcoholism Clinical and Experimental Research, 33(9), 1539-44. [PDF]

Leventhal. A.M., Waters, A.J., Kahler, C.W., Ray, L.A., & Sussman, S. (2009). Relations between anhedonia and smoking motivation. Nicotine & Tobacco Research, 11(9), 1047-54. [PDF]

MacKillop, J., Murphy, J.G., Tidey, J., Kahler, C., Ray, L.A., & Bickel, W. (2009). Latent structure of the facets of alcohol reinforcement from a behavioral economic demand curve. Psychopharmacology, 203(1), 33-40. [PDF]

Leventhal, A.M., Kahler, C.W., Ray, L.A., & Zimmerman, M. (2009). Refining the depression-nicotine dependence link: patterns of depressive symptoms in psychiatric outpatients with current, past, and no history of nicotine dependence. Addictive Behaviors, 34(3), 297-303. [PDF]

Ray, L.A.,Hutchison, K.E., & Hauser, M. (2008). Alcohol use disorders: history, theory, and diagnosis. In W.E. Craighead, D.J. Miklowitz, & L.C. Craighead (Eds.). Psychopathology: History, Diagnosis, and Empirical Foundations (pp. 495-523). John Wiley and Sons.

Ray, L.A., Hutchison, K.E., MacKillop, J., Miranda, R. Jr., Audette, A., Swift, R., & Monti, P.M. (2008). Effects of naltrexone during the descending limb of the blood alcohol curve. American Journal on Addictions, 17(4), 257-264. [PDF]

Ray, L.A., Miranda Jr., R., Young, D., Chelminski, I., & Zimmerman, M. (2008). Diagnostic orphans for alcohol use disorders in a treatment-seeking psychiatric sample. Drug and Alcohol Dependence, 96(1-2), 187-191. [PDF]

Ray, L.A., Kahler, C., Young, D., Chelminski, I., & Zimmerman, M. (2008). The factor structure and severity of DSM-IV alcohol abuse and dependence symptoms in psychiatric outpatients. Journal of Studies on Alcohol and Drugs, 69(4), 496-499. [PDF]

Leventhal, A.M., Kahler, C.W., Ray, L.A., Stone, K., & Zimmerman, M. (2008). Anhedonia and amotivation in psychiatric outpatients with fully remitted stimulant use disorder. American Journal on Addictions, 17(3), 218-223. [PDF]

Haughey, H.M., Ray, L.A., Finan, P., Villanueva, R., Nicolescu, M., & Hutchison, K.E. (2008). The Human GABA_A Receptor alpha 2 Gene Moderates the Acute Effects of Alcohol and Brain mRNA Expression. Genes, Brain, and Behavior, 7(4), 447-454.

Filbey, F., Ray, L.A., Smolen, A., Claus, E., Audette, A., & Hutchison, K.E. (2008). Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotype. Alcoholism Clinical and Experimental Research, 32(7), 1113-1123. [PDF]

MacKillop, J., Murphy, J.G., Ray, L.A., Eisenberg, D.T.A., Lisman, S.A., Lum, J.K., & Wilson, D.S. (2008). Further validation of the cigarette purchase task for assessing the relative reinforcing efficacy of nicotine in college smokers. Experimental and Clinical Psychopharmacology, 16(1), 57-65. [PDF]

Miranda, R. Jr., Rohsenow, D.J., Monti, P.M., Tidey, J., & Ray, L.A. (2008). Effects of repeated days of smoking cue-exposure on urge to smoke and physiological reactivity. Addictive Behaviors, 33(2), 347-353. [PDF]

Miranda, R. Jr., MacKillop J., Monti, P.M., Rohsenow, D.J., Tidey, J., Gwaltney, C., Swift, R., Ray, L.A., & McGeary, J.E. (2008). Effects of topiramate on urge to drink and the subjective effects of alcohol consumption. Alcoholism Clinical and Experimental Research, 32(3), 489-497. [PDF]

Ray, L.A., & Hutchison, K.E. (2007). Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: A double-blind placebo-controlled study. Archives of General Psychiatry, 64(9), 1069-1077. [PDF]

Ray, L.A., Miranda, R. Jr., Kahler, C.M., Leventhal, A.M., Monti, P.M., Swift, R., & Hutchison, K.E. (2007). Pharmacological effects of naltrexone and intravenous alcohol on craving for cigarettes: A pilot study. Psychopharmacology, 193(4), 449-456. [PDF]

Ray, L.A., Rhee, S.H., Stallings, M.S., Knopik, V., & Hutchison, K.E. (2007). Examining the heritability of a laboratory-based smoking endophenotype: Initial Results from an experimental twin study. Twin Research and Human Genetics, 10(4), 546-553.

Ray, L.A., MacKillop, J., & Hutchison, K.E. (2007). Pharmacogenetics of the mu-opioid receptor and the treatment of addictions. Personalized Medicine, 4(2), 217-220.

Ray, L.A., Meskew-Stacer, S., & Hutchison, K.E. (2007). The relationship between prospective self-rating of alcohol sensitivity and craving and experimental results from two alcohol challenge studies. Journal of Studies on Alcohol and Drugs, 68(3), 379-384.

Bryan, A., Ray, L.A., & Cooper, M.L. (2007). Alcohol use and protective sexual behaviors among high-risk adolescents: A prospective analysis. Journal of Studies on Alcohol and Drugs, 68(3), 327-335. [PDF]

Ray, L.A., Hutchison, K.E., & Bryan, A. (2006). Psychosocial predictors of treatment outcome, dropout, and change processes in a pharmacological clinical trial for alcohol dependence. Addictive Disorders and Their Treatment, 5(4), 179-190.

Ray, L.A., McGeary, J., Marshall, E., & Hutchison, K.E. (2006). Risk factors for alcohol misuse: Integrating heart rate response to alcohol, alcohol sensitivity, and personality constructs. Addictive Behaviors, 31(1), 1959-1973. [PDF]

Hutchison, K.E., Ray, L.A., Sandman, E., Rutter, M.C., Peters, A., & Swift, R. (2006). The effect of olanzapine on craving and alcohol consumption. Neuropsychopharmacology, 31, 1310-1317. [PDF]

Hines, L., Ray, L.A., Hutchison, K.E., & Tabakoff, B. (2005). Alcoholism: The dissection for endophenotypes. Dialogues in Clinical Neuroscience, 7(3), 153-163.

Ray, L.A., & Hutchison, K. E. (2004). A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. Alcoholism Clinical and Experimental Research, 28, 1789-1795. [PDF]

Fromme, K., de Witt, H., Hutchison, K.E., Ray, L.A., Corbin, W.R., Cook, T.A., & Wall, T.L. (2004). Biological and behavioral markers of alcohol sensitivity. Alcoholism Clinical and Experimental Research, 28(2), 247-256. [PDF]